Antibodies and methods for the diagnosis and treatment of Epstein Barr virus infection

US12410240B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. · US

Inventors

• Wei Bu · Potomac, US
• Masaru Kanekiyo · Bethesda, US
• Michael Gordon Joyce · Washington, US
• Jeffrey I. Cohen · Watertown, US

Key dates

• Filing date: Feb 13, 2024
• Grant date: Sep 9, 2025
• Expiry date: Feb 13, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/565
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus (EBV) infection in mammals, and methods of using those compositions of matter for the detection, diagnosis and treatment of EBV infection are described. Also described are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.