CRISPR enzymes and systems

US12410468B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US

Inventors

• Feng Zhang · Cambridge, US
• Bernd Zetsche · Cambridge, US
• Jonathan Gootenberg · Cambridge, US
• Omar Abudayyeh · Cambridge, US
• Ian Slaymaker · Cambridge, US

Key dates

• Filing date: Sep 28, 2020
• Grant date: Sep 9, 2025
• Expiry date: May 14, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/80
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.