Methods and compositions for optochemical control of CRISPR-CAS9
US12421507B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Aug 20, 2019 |
| Grant date | Sep 23, 2025 |
| Priority date | — |
| Expiry date | Jan 22, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The disclosure includes non-naturally occurring or engineered DNA- or RNA-guided nuclease systems, comprising CRISPR enzymes associated with at least one destabilization domain (DD) and photocaged stabilization ligands with at least one photocage molecule, along with compositions, systems and complexes involving such systems, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.