1,2,4-triazin-3(2H)-one compounds for the treatment of hyperproliferative diseases

US12427153B2 · kind B2 · utility

Assignees

• BAYER HEALTHCARE LLC · DE
• The Broad Institute, Inc. · US

Inventors

• Stefan Nikolaus Gradl · Berlin, DE
• Manuel Ellermann · Berlin, DE
• Philip Lienau · Berlin, DE
• Charlotte Christine Kopitz · Falkensee, DE
• Martin Lange · Berlin, DE
• Adrian Tersteegen · Wuppertal, DE
• Detlev Sülzle · Berlin, DE
• Timothy A. Lewis · Marlborough, US
• Heidi Greulich · Cambridge, US
• Xiaoyun Wu · Chesterfield, US

Key dates

• Filing date: Jul 30, 2021
• Grant date: Sep 30, 2025
• Expiry date: Sep 30, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention includes name compounds of general formula (I): (I) in which R1, R2, R3 and R4 are as defined herein, methods for their preparation, pharmaceutical compositions and combinations comprising said compounds, and their use for the treatment of hyperproliferative diseases.