Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels

US12427159B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Anthony J. Roecker · Harleysville, US
• Mark E. Layton · Harleysville, US
• Deping Wang · Furlong, US
• Xiu Wang · Shanghai, CN
• Xuanjia Peng · Shanghai, CN

Key dates

• Filing date: Jun 8, 2020
• Grant date: Sep 30, 2025
• Expiry date: Jan 1, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula A, or a salt thereof: Wherein “A1”, R1, R2, R3, R6, and R7 are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch and neuropathic pain disorders using the same.