Dopamine D2 receptor ligands

US12428373B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US

Inventors

• Edward Holson · Newton, US
• Florence Fevrier Wagner · Ashland, US
• Michel Weiwer · Cambridge, US
• Edward Scolnick · Wayland, US
• Michelle Palmer · Harvard, US
• Luka Dordevic · Trieste, IT
• Michael C. Lewis · Dedham, US
• Jennifer Q. Pan · Acton, US
• Yan Zhang · Fort Washington, US
• Qihong Xu · Newton, US

Key dates

• Filing date: Oct 7, 2022
• Grant date: Sep 30, 2025
• Expiry date: Dec 18, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/70571
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.