Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
US12428682B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Jun 9, 2021 |
| Grant date | Sep 30, 2025 |
| Priority date | — |
| Expiry date | Mar 6, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/172
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods are provided for predicting a subject's infection status using high-throughput T cell receptor sequencing to match the subject's TCR repertoire to a known set of disease-associated T cell receptor sequences. The methods of the present invention may be used to predict the status of several infectious agents in a single sample from a subject. Methods are also provided for predicting a subject's HLA status using high-throughput immune receptor sequencing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.