5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, method for their use as antibacterial agents and compositions useful therefor
US4053591A · kind A · utility
8Cited by
6References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 30, 1976 |
| Grant date | Oct 11, 1977 |
| Priority date | — |
| Expiry date | Jun 30, 1996 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/863
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, useful antibacterial agents, are prepared by the reaction of the corresponding 5-O-thioformyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol having all amino functions and all primary and secondary hydroxyl groups protected, with an organotin hydride (preferably tri-n-butylstannane) in an inert aprotic solvent under an inert atmosphere at temperatures of at least about 100.degree. C, followed by removal of said hydroxyl and amino protecting groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.