Intermediates in the total synthesis employing substituted isoxazole derivatives
US4080334A · kind A · utility
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4Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 14, 1976 |
| Grant date | Mar 21, 1978 |
| Priority date | — |
| Expiry date | Jun 14, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19.beta.-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.