Dihydrocarbazole acetic acid and esters thereof
US4146542A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 12, 1978 |
| Grant date | Mar 27, 1979 |
| Priority date | — |
| Expiry date | Jun 12, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing 6-chloro-.alpha.-methylcarbazole-2-acetic acid and esters thereof by the steps of: (a) reacting 6-chloro-1,2,3,4-tetrahydrocarbazole-2-one with a trialkyl-.alpha.-methylphosphonoacetate to yield the corresponding 3,4-dihydro-.alpha.-methylcarbazole-2-acetic acid ester; and (b) aromatizing the reaction product of step (a), prior to or after saponification, to yield, respectively, 6-chloro-.alpha.-methylcarbazole-2-acetic acid or ester, is described. Additionally, there are described 6-chloro-1,2,3,4-tetrahydrocarbazole-2-one useful as an intermediate, and dihydrocarbazoles useful as intermediates and/or as anti-inflammatory and antirheumatic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.