D-Homopregnanes

US4202841A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Leo Alig · Kaiseraugst, CH
• Andor Furst · Basel, CH
• Marcel Muller · Frenkendorf, CH
• Ulrich Kerb
• Klaus Kieslich · Braunschweig, DE
• Rudolf Wiechert · Berlin, DE

Key dates

• Filing date: Dec 26, 1978
• Grant date: May 13, 1980
• Expiry date: Dec 26, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P33/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

D-Homopregnanes of the formula ##STR1## wherein the dotted line in the 1,2-position together with the corresponding solid line denotes a single or double carbon-carbon bond; R.sup.6 is hydrogen, fluoro, chloro or methyl; R.sup.9 is hydrogen, fluoro, chloro or bromo; R.sup.11 is hydroxyl, acyloxy, fluoro or chloro; and R.sup.17a is hydroxyl or acyloxy with the proviso that when R.sup.9 is fluoro, chloro or bromo and R.sup.11 is fluoro or chloro, the atomic number of R.sup.11 is less than or equal to that of R.sup.9 ; and with the further proviso that when R.sup.6 is hydrogen, and R.sup.11 and R.sup.17a are hydroxy or when R.sup.6 is fluoro, R.sup.11 and R.sup.17a are hydroxyl and the dotted line in the 1,2-position together with the corresponding solid line denotes a single carbon-carbon bond, R.sup.9 is fluoro, chloro or bromo and processes for the preparation thereof are disclosed.