Patent · US Expired

2'-Hydroxy-2'-desamino-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, method for their use as antibacterial agents, and compositions useful therefor

US4212859A · kind A · utility

13Cited by

3References

20Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Peter J. L. Daniels · Cedar Grove, US
Stuart W. McCombie · Caldwell, US
Tattanahalli L. Nagabhushan · Parsippany, US

Key dates

Filing date	Jun 5, 1978
Grant date	Jul 15, 1980
Priority date	—
Expiry date	Jun 5, 1998

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

2'-Hydroxy-2'-desamino-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols having a 6'-amino function exhibit antibacterial activity and are prepared by reaction of the corresponding N-protected (except the 2'-amino)-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol with hydrogen peroxide in the presence of tungstate ion, followed by cleavage of the thereby formed 2'-oximino derivative, thence reduction of the resulting 2'-oxo derivative and removal of the N-protecting groups. Preferred compounds are 1-N-(.omega.-amino-.alpha.-hydroxyalkanoyl)-2'-hydroxy-2'-desamino-4,6-di- O-(aminoglycosyl)-1,3-diaminocyclitols which exhibit antibacterial activity against bacteria resistant to the parent aminoglycoside.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.