Process of making a carbazole acetic acid
US4234487A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 1979 |
| Grant date | Nov 18, 1980 |
| Priority date | — |
| Expiry date | May 3, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/88
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing 6-chloro-.alpha.-methylcarbazole-2-acetic acid and esters thereof by the steps of: PA0 (a) reacting 6-chloro-1,2,3,4-tetrahydrocarbazole-2-one with a trialkyl-.alpha.-methylphosphonoacetate to yield corresponding 3,4-dihydro-.alpha.-methylcarbazole-2-acetic acid ester; and PA0 (b) aromatizing the reaction product of step (a), prior to or after saponification, to yield, respectively, 6-chloro-.alpha.-methylcarbazole-2-acetic acid or ester, is described. Additionally, there are described 6-chloro-1,2,3,4-tetrahydrocarbazole-2-one useful as an intermediate, and dihydrocarbazoles useful as intermediates and/or as anti-inflammatory and antirheumatic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.