Patent · US Expired

N-substituted dimeric cyclopeptide derivatives and preparation thereof

US4252795A · kind A · utility

2Cited by

0References

3Claims

0Family size

Assignee

Ayerst, McKenna & Harrison, Inc. · CA

Inventors

Amedeo A. Failli · Princeton Junction, US
Hans U. Immer · Mount Royal, CA
Manfred Götz · Brakel, DE

Key dates

Filing date	Sep 11, 1978
Grant date	Feb 24, 1981
Priority date	—
Expiry date	Sep 11, 1998

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S930/27
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The N-substituted dimeric cyclopeptide derivatives of formula ##STR1## in which A is a peptide residue having one to four amino acid residues; R.sup.1 is lower alkyl, phenyl or pheny(lower) alkylene; R.sup.2 is lower alkyl, cyclo(lower)alkyl or lower alkoxycarbonyl(lower)alkylene; R.sup.3 is a neutral amino acid side chain and a method for the preparation of the compounds of formula I are disclosed. The compounds of formula I are useful for treating microbial infections. Pharmaceutical compositions also are disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.