.alpha.-Acetylenic derivatives of .alpha.-amino acids
US4260823A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 2, 1979 |
| Grant date | Apr 7, 1981 |
| Priority date | — |
| Expiry date | Jul 2, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C237/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel acetylenic derivatives of .alpha.-amino acids of the following general structure: ##STR1## wherein R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR2## is hydrogen, a straight or branched lower alkyl group of 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; each R.sub.1 is the same and is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.3 R.sub.4 wherein each of R.sub.3 and R.sub.4 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms and can be the same or different, or ##STR3## wherein R.sub.5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; and pharmaceutically acceptable salts and individual optical isomers thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.