6-(Substituted-hydroxymethylene penams)
US4272439A · kind A · utility
12Cited by
6References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 2, 1978 |
| Grant date | Jun 9, 1981 |
| Priority date | — |
| Expiry date | Jun 2, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D505/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
.beta.-Lactams having a substituted hydroxymethylene group at the position .alpha. to the lactam carbonyl group are prepared by reaction of an .alpha.-halo-.beta.-lactam with zinc or zinc amalgam in an anhydrous aprotic medium to produce an intermediate which in situ reacts with an appropriate aldehyde or ketone. Also described are noval penicillins and cephalosporins having useful antibacterial activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.