Synthesis of .beta.-lactams having a substituted hydroxymethylene group at the position .alpha. to the lactam carbonyl group
US4283531A · kind A · utility
7Cited by
3References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 4, 1979 |
| Grant date | Aug 11, 1981 |
| Priority date | — |
| Expiry date | Oct 4, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D505/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
.beta.-Lactams having a substituted hydroxymethylene group at the position .alpha. to the lactam carbonyl group are prepared by reaction of an .alpha.-halo-.beta.-lactam with zinc or zinc amalgam in an anhydrous aprotic medium to produce an intermediate which in situ reacts with an appropriate aldehyde or ketone. Also described are novel penicillins and cephalosporins having useful antibacterial activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.