Process for 1.alpha.,3.beta.-dihydroxy-.DELTA..sup.5 -steroids
US4305881A · kind A · utility
3Cited by
1References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 13, 1979 |
| Grant date | Dec 15, 1981 |
| Priority date | — |
| Expiry date | Nov 13, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/001
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the synthesis of 1.alpha.,3.beta.-dihydroxy-.DELTA..sup.5 -steroids from steroids such as 1.alpha.,2.alpha.-epoxy-cholesta-4,6-dien-3-one, which is reacted with lithium in liquid ammonia in the absence of a proton donator and subsequently reduced by repeated alternative additions of a proton donator, said additions being followed in each case by an equivalent amount of lithium. The final product, a 1.alpha.,3.beta.-dihydorxy-.DELTA..sup.5 -steroid, is useful in the synthesis of derivatives of cholecalciferol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.