Process and intermediates for the synthesis of vitamin D.sub.3 metabolites
US4310467A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 22, 1980 |
| Grant date | Jan 12, 1982 |
| Priority date | — |
| Expiry date | Oct 22, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J53/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D.sub.3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D.sub.3 metabolites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.