Process and intermediates for the synthesis of Vitamin D.sub.3 metabolites and chenodeoxycholic acid
US4360470A · kind A · utility
5Cited by
1References
43Claims
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Key dates
| Filing date | Oct 22, 1980 |
| Grant date | Nov 23, 1982 |
| Priority date | — |
| Expiry date | Oct 22, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J13/007
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure is directed to a process for the synthesis of chenodeoxychloic acid, 25-hydroxycholesterol and 1.alpha.,25-dihydroxycholesterol from 17-keto steroids. A cholic acid side chain is stereospecifically introduced by reaction of the appropriate 17-keto steroid with ethyltriphenylphosphonium halides to produce the 17-ethylidene derivative which is allowed to react with acrylic acid esters or propiolic acid esters followed by hydrogenation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.