Filaricidal 2-nitroimidazole compounds
US4366166A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 14, 1981 |
| Grant date | Dec 28, 1982 |
| Priority date | — |
| Expiry date | May 14, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P33/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2-Nitroimidazoles having filaricidal activity of the formula ##STR1## wherein A is one of the groups ##STR2## --C(R.sup.3).dbd.C(R.sup.1)(R.sup.2),--CHBr--CH.sub.2 Br or --CH.sub.2 --CCl.dbd.CH.sub.2 ; PA0 n is 1, 2, 3 or 4; PA0 R.sup.1 and R.sup.2 are hydrogen or C.sub.1-3 -alkyl and PA0 R.sup.3 is hydrogen, C.sub.1-3 -alkyl, chlorine or bromine, and processes for their preparation are described. The compounds of formula I and compounds of formula ##STR3## wherein R.sup.4 is --CH.sub.2 --CH.sub.2 OH, --CH.sub.2 --CHOH--CH.sub.2 OCH.sub.3, --CH.sub.2 --CHOH--CH.sub.2 OH or ##STR4## are useful in the treatment of filariasis is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.