Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells

US4371540A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• William W. Lee · Arcadia, US
• J. Martin Brown · Redwood City, US
• Abelardo P. Martinez · San Jose, US
• Michael Cory · Chapel Hill, US

Key dates

• Filing date: Aug 22, 1980
• Grant date: Feb 1, 1983
• Expiry date: Aug 22, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Two compounds represented by the formula ##STR1## wherein R is hydrogen or a 2-hydroxyethyl radical are reported to have minimum penetration into the brain and nerve tissues combined with maximum penetration into hypoxic tumor cells. This combination of properties makes these compounds the optimal radiosensitizers among electron-affinic 1-substituted 2-nitroinidazoles.