The United States of America as Represented by the Secretary of the Department of Health and Human Services
672Patents
261Active
672Granted
53Portfolio score
Filing activity: Mar 19, 1979 → Oct 1, 2020 · 156 expiring within 5 years
Most-cited patents
| Patent | Title | Area | Cited by | Status |
|---|---|---|---|---|
| US4676980A | Target specific cross-linked heteroantibodies | Emerging Cross-Sectional Technologies | 1,113 | Expired |
| US5525711A | Pteridine nucleotide analogs as fluorescent DNA probes | Chemistry; Metallurgy | 520 | Expired |
| US4829000A | Reconstituted basement membrane complex with biological activity | Emerging Cross-Sectional Technologies | 206 | Expired |
| US4300557A | Method for treating intraocular malignancies | Human Necessities | 180 | Expired |
| US4520113A | Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions | Emerging Cross-Sectional Technologies | 167 | Expired |
| US5678550A | Apparatus and method for in situ detection of areas of cardiac electrical activity | Human Necessities | 154 | Expired |
| US5840839A | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein | Emerging Cross-Sectional Technologies | 137 | Expired |
| US5255675A | Device for intratracheal ventilation and intratracheal pulmonary ventilation | Human Necessities | 131 | Expired |
| US6468524B1 | AAV4 vector and uses thereof | Chemistry; Metallurgy | 130 | Expired |
| US4827125A | Confocal scanning laser microscope having no moving parts | Physics | 120 | Expired |
| US4604094A | Toposcopic catheter and method of fabrication | Human Necessities | 112 | Expired |
| US4943579A | Water soluble prodrugs of camptothecin | Human Necessities | 105 | Expired |
| US6403635B1 | Method of treating atherosclerosis or restenosis using microtubule stabilizing agent | Human Necessities | 105 | Expired |
| US4588993A | Broadband isotropic probe system for simultaneous measurement of complex E- and H-fields | Electricity | 105 | Expired |
| US5474089A | Method and device for reversible sterilization | Human Necessities | 104 | Expired |
| US5155137A | Complexes of nitric oxide with polyamines | Chemistry; Metallurgy | 103 | Expired |
| US5650447A | Nitric oxide-releasing polymers to treat restenosis and related disorders | Chemistry; Metallurgy | 101 | Expired |
| US5366997A | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs | Chemistry; Metallurgy | 96 | Expired |
| US5635532A | Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia | Human Necessities | 93 | Expired |
| US6713446B2 | Formulation of boronic acid compounds | Human Necessities | 90 | Expired |
| US5081871A | Breath sampler | Physics | 82 | Expired |
| US7316903B2 | Detection of nucleic acid sequence variations using phase Mu transposase | Chemistry; Metallurgy | 81 | Expired |
| US4831175A | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate | Human Necessities | 81 | Expired |
| US6013433A | Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus | Physics | 80 | Expired |
| US4612282A | Monoclonal antibodies reactive with human breast cancer | Physics | 79 | Expired |
Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.