Method of the production of immunoglobulin having high content of monomer
US4384993A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 8, 1980 |
| Grant date | May 24, 1983 |
| Priority date | — |
| Expiry date | Aug 8, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/831
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of the production of immunoglobulin having a high content of monr from immunoglobulin-containing materials by a fractionation method, which comprises carrying out the fractionation in the presence of a water-soluble, basic nitrogen-containing organic compound having a dissociation constant (pKb) of 7 or less or an acid addition salt thereof, and thereby inhibiting by-production of undesirable aggregated molecules. The immunoglobulin has a high content of monomer and contains no or little aggregated molecules and hence can be used as a medicine in immune prophylaxis and immunotherapy without undesirable side effects and can be administered by intraveneous route, and further, is useful for the preparation of chemically treated immunoglobulin having a high content of monomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.