Mannose-6-phosphate-low density protein reagent effective against hypercholesterolemia

US4397843A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• David M. Neville, Jr. · Bethesda, US
• Richard J. Youle · Bethesda, US
• Gary Murray · Bethesda, US

Key dates

• Filing date: Jan 21, 1982
• Grant date: Aug 9, 1983
• Expiry date: Jan 21, 2002

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A new reagent effective in inhibiting cholesterol synthesis 75% in human fibroblasts derived from patients suffering from the disease familial hypercholestrolemia is Man6P-low density lipoprotein and is effective in tissue culture test systems at 100 .mu.g/ml after a ten-hour exposure. The broad purpose of this invention is to modify the receptor specificity of a protein so that it will enter cells which were previously impermeable and exert new effects or reverse a pathological condition. That is, the compound of this invention is a useful reagent in the selective cytotoxic treatment of hypercholesterolemia.