The United States of America, as represented by the Department of Health and Human Services
1,976Patents
203Active
1,976Granted
56Portfolio score
Filing activity: May 30, 1975 → Mar 17, 2022 · 193 expiring within 5 years
Most-cited patents
| Patent | Title | Area | Cited by | Status |
|---|---|---|---|---|
| US6143496A | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly | Emerging Cross-Sectional Technologies | 915 | Expired |
| US5399346A | Gene therapy | Human Necessities | 723 | Expired |
| US5756476A | Inhibition of cell proliferation using antisense oligonucleotides | Chemistry; Metallurgy | 678 | Expired |
| US5264423A | Inhibitors for replication of retroviruses and for the expression of oncogene products | Chemistry; Metallurgy | 657 | Expired |
| US5276019A | Inhibitors for replication of retroviruses and for the expression of oncogene products | Chemistry; Metallurgy | 582 | Expired |
| US5286717A | Inhibitors for replication of retroviruses and for the expression of oncogene products | Chemistry; Metallurgy | 529 | Expired |
| US6207646A | Immunostimulatory nucleic acid molecules | Emerging Cross-Sectional Technologies | 467 | Expired |
| US6239116A | Immunostimulatory nucleic acid molecules | Emerging Cross-Sectional Technologies | 454 | Expired |
| US4797368A | Adeno-associated virus as eukaryotic expression vector | Chemistry; Metallurgy | 440 | Expired |
| US4727064A | Pharmaceutical preparations containing cyclodextrin derivatives | Chemistry; Metallurgy | 386 | Expired |
| US4690915A | Adoptive immunotherapy as a treatment modality in humans | Human Necessities | 320 | Expired |
| US6246784A | Method for segmenting medical images and detecting surface anomalies in anatomical structures | Physics | 316 | Expired |
| US4419446A | Recombinant DNA process utilizing a papilloma virus DNA as a vector | Chemistry; Metallurgy | 278 | Expired |
| US6713081B2 | Ocular therapeutic agent delivery devices and methods for making and using such devices | Emerging Cross-Sectional Technologies | 272 | Expired |
| US5616608A | Method of treating atherosclerosis or restenosis using microtubule stabilizing agent | Human Necessities | 259 | Expired |
| US6982146B1 | High speed parallel molecular nucleic acid sequencing | Chemistry; Metallurgy | 230 | Expired |
| US5720720A | Convection-enhanced drug delivery | Human Necessities | 229 | Expired |
| US5474935A | Adeno-associated virus (AAV)-based eucaryotic vectors | Chemistry; Metallurgy | 210 | Expired |
| US8067159B2 | Methods of detecting amplified product | Emerging Cross-Sectional Technologies | 202 | Active |
| US7122033B2 | Endoluminal radiofrequency cauterization system | Human Necessities | 202 | Expired |
| US4601903A | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease | Human Necessities | 196 | Expired |
| US4476870A | Fiber optic P.sub.O.sbsb.2 probe | Physics | 193 | Expired |
| US6676657B2 | Endoluminal radiofrequency cauterization system | Human Necessities | 181 | Expired |
| US4873192A | Process for site specific mutagenesis without phenotypic selection | Chemistry; Metallurgy | 180 | Expired |
| US5525357A | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same | Chemistry; Metallurgy | 174 | Expired |
Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.