N-Substituted dimeric cyclopeptide derivatives

US4401656A · kind A · utility

Assignee

• Ayerst, McKenna & Harrison, Inc. · CA

Inventors

• Amedeo A. Failli · Princeton Junction, US
• Hans U. Immer · Mount Royal, CA
• Manfred Götz · Brakel, DE

Key dates

• Filing date: Sep 22, 1980
• Grant date: Aug 30, 1983
• Expiry date: Sep 22, 2000

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/27
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The N-substituted dimeric cyclopeptide derivatives of formula ##STR1## in which A is a peptide residue having one to four amino acid residues; R.sup.1 is lower alkyl, phenyl or phenyl(lower)alkylene; R.sup.2 is lower alkyl, cyclo(lower)alkyl or lower alkoxycarbonyl(lower)alkylene; and R.sup.3 is a neutral amino acid side chain and a method for the preparation of the compounds of formula I are disclosed. The compounds of formula I are useful for treating microbial infections. Pharmaceutical compositions also are disclosed.