Separation of triphenylphosphine oxide from methotrexate ester and purification of said ester
US4421913A · kind A · utility
6Cited by
2References
2Claims
0Family size
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Key dates
| Filing date | Dec 11, 1981 |
| Grant date | Dec 20, 1983 |
| Priority date | — |
| Expiry date | Dec 11, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improvement in the production of methotrexate as set out in Ellard U.S. Pat. No. 4,080,325. It has been found that magnesium oxide facilitates the coupling reaction by acting as an acid acceptor. The dense grade of magnesium oxide is preferred in molar proportions of 2 to 4 moles of magnesium oxide per mole of 2,4-diamino-6-hydroxymethylpteridine. Further, the triphenylphosphine oxide which is generated by hydrolysis of the protecting groups is removed from the reaction stream by utilization of toluene or BTX-type solvents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.