Leucocyte adherence inhibition assay for detection of cancer
US4426446A · kind A · utility
5Cited by
4References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 3, 1981 |
| Grant date | Jan 17, 1984 |
| Priority date | — |
| Expiry date | Feb 3, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/813
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for carrying the leucocyte adherence inhibition (LAI) assay for detecting the presence of cancer in responsive patients. One aspect of the invention utilizes incubation with agents which maximize the intracellular cycle 3',5'-adenosine monophosphate (cAMP) levels in the leucocytes as a means to expand the percentage of responding subjects in different cancers. A second aspect utilizes measurement of extracted, vital cell dye to avoid the need of counting the adhering or non-adhering leucocytes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.