Heterocyclic compounds containing an alkoxycarbonyl and a substituted methyl group
US4435322A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 11, 1981 |
| Grant date | Mar 6, 1984 |
| Priority date | — |
| Expiry date | Sep 11, 2001 |
Classification
- Technology area (CPC E)Fixed Constructions
- CPC primaryE04G2009/025
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to new heterocyclic compound containing an alkoxycarbonyl and a substituted methyl group a process for the preparation of these and analogeous compound and pharmaceutical compositions containing them. More particularly, the invention concerns compounds of the general formula (IVa) ##STR1## wherein R' is hydrogen, 2-ethoxycarbonylethyl, aryl or a group suitable for a temporary protection of amides and PA0 Y' represents a group of the formula --COOZ or --CH.sub.2 M, in which PA1 Z is lower alkyl and PA1 M is hydroxyl, halogen, cyano or a group of the formula --O--SO.sub.2 R.sup.2, in which PA2 R.sup.2 is lower alkyl or aryl, with the proviso that if R' is phenyl, Y' cannot stand for the group --COOC.sub.2 H.sub.5. The invention further relates to a process for the preparation of compounds of the general formula (IV) ##STR2## in which R and Y are identical with R' and Y', respectively, except the proviso. According to a further aspect of the invention there are provided pharmaceutical compositions, first of all with antihypoxic activity, comprising compounds of the general formula (IVa) as active ingredient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.