Reactor system and method for polynucleotide synthesis
US4483964A · kind A · utility
51Cited by
1References
18Claims
0Family size
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Key dates
| Filing date | Jun 20, 1983 |
| Grant date | Nov 20, 1984 |
| Priority date | — |
| Expiry date | Jun 20, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/82
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A reactor system and method for synthesizing or degrading polynucleotides and other linear polymers includes a tubular reactor connected to a reagent manifold. The polynucleotide is immobilized on a loosely packed solid-phase support material in the tubular reactor, and reagents are sequentially introduced into the tubular reactor. After each reagent is introduced, the tubular reactor is isolated from the reagent manifold and the reagent agitated by alternately pressurizing the opposite ends of the tubular reactor. The method provides rapid and efficient synthesis of polynucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.