Composition and method for transplantation therapy
US4489710A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 18, 1982 |
| Grant date | Dec 25, 1984 |
| Priority date | — |
| Expiry date | Oct 18, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/866
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An improved transplantion therapy and method is provided which comprises specifically killing cells known to be problematic in the transplantion process. Novel compositions of the present invention are conjugates prepared by generating antibodies specific to surface receptors of the unwanted cells, preparing Fab or F(ab').sub.2 fragments from the antibodies, and coupling the fragments to A chains of lectins or other cytotoxic agents to render the conjugates thus formed strongly cytotoxic to the cells to which the antibody was directed. The conjugates are used in vitro to eliminate unwanted cells prior to bone marrow transplantation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.