Stabilizing agents for live viruses for preparing vaccines, and stabilized vaccines containing said stabilizing agents
US4500512A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 5, 1982 |
| Grant date | Feb 19, 1985 |
| Priority date | — |
| Expiry date | May 5, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The stabilizing agent is constituted by a phosphate buffer solution (PBS) containing calcium and magnesium ions, which contains in addition lactose, sorbitol and at least one amino acid taken from the group which comprises histidine, alanine, valine, threonine, arginine, methionine, hydroxyproline, lysine, isoleucine, phenylalanine, serine, and preferably constituted by an association of histidine and alanine. The stabilized vaccine is constituted by a suspension of live attenuated viruses in the above stabilizing agent, and lyophilized. The invention also relates to the method for preparing such a stabilized vaccine, to the stabilized vaccines so-obtained and to their use for treating viral diseases in humans or animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.