Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions
US4520113A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 23, 1984 |
| Grant date | May 28, 1985 |
| Priority date | — |
| Expiry date | Apr 23, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/811
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention relates to the detection of antibodies in sera of AIDS and pre-AIDS patients and describes the biochemical and immunological analysis of antigens associated with the virus HTLV-III Human T-Cell Leukemia Virus. It is shown that antigens associated with the infection of human cells by this virus are specifically recognized by antibodies from AIDS patients. Specifically, HTLV-III isolated from AIDS patients and transmitted by cocultivation with an HT cell line is specifically detected by antibodies from human sera taken from AIDS patients. The method of detection of antibodies preferred is a strip radioimmunoassay (RIA) based on the Western Blot technique or an ELISA (an enzyme-linked immunosorbent assay) or an indirect immunofluorescence assay.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.