Metaphit, a specific acylating agent for the [.sup.3 H] phencyclidine

US4598153A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Kenner C. Rice · Bethesda, US
• Michael Francis Rafferty · Wheeling, US
• Arthur E. Jacobson · Rockville, US
• Patricia C. Contreras · West Chester, US
• Thomas L. O'Donohue · Chesterfield, US
• Ralph A. Lessor · New Providence, US
• Mariena V. Mattson · Rockville, US

Key dates

• Filing date: Dec 19, 1984
• Grant date: Jul 1, 1986
• Expiry date: Dec 19, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/36
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A derivative of phencyclidine (1) bearing an isothiocyanate moiety of the meta position of the aromatic ring (2; Metaphit) has been synthesized and identified as a rapid and specific site-directed acylating agent of the [.sup.3 H]-phencyclidine binding site in rat brain homogenates.