Isolation of hepatitis A virus strain HM-175

US4636469A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Richard J. Daemer · Washington, US
• Stephen M. Feinstone · Boyds, US
• Ian D. Gust · Parramatta, AU
• Robert H. Purcell · Boyds, US

Key dates

• Filing date: Dec 26, 1984
• Grant date: Jan 13, 1987
• Expiry date: Dec 26, 2004

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Human hepatitis A virus (HAV), taken directly from human clinical specimens, can be isolated and serially passaged in primary African green monkey kidney (AGMK) cell cultures. This strain induced antibody to HAV in inoculated chimpanzees and is useful for vaccine.