Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4681893A · kind A · utility
252Cited by
7References
9Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 30, 1986 |
| Grant date | Jul 21, 1987 |
| Priority date | — |
| Expiry date | May 30, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Certain trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.