Temperature sensitive reassortant viruses and a vaccine against equine influenza

US4683137A · kind A · utility

Assignee

• Cornell Research Foundation, Inc. · US

Inventors

• Leroy Coggins · Ithaca, US
• Brian R. Murphy · Bethesda, US
• Dorothy F. Holmes · Groton, US
• Lynne J. Anguish · Ithaca, US
• James H. Gillespie · Ithaca, US

Key dates

• Filing date: Jul 26, 1984
• Grant date: Jul 28, 1987
• Expiry date: Jul 26, 2004

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S424/821
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a method and resulting temperature-sensitive (ts) reassortant virus produced by modifying wild-type equine influenza viruses by utilizing mutagenized human influenza viruses possessing ts lesions and shut off temperatures in the area of 37.degree.-39.degree. C., preferably 37.degree.-38.degree. C. When utilized as a vaccine for equines, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms while producing protection against infectious equine influenzal disease.