Novel synthetic peptide, process for its preparation and medicaments containing it
US4686281A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 24, 1984 |
| Grant date | Aug 11, 1987 |
| Priority date | — |
| Expiry date | Aug 24, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/975
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a synthetic peptide comprising at least 5 of the 11 amino acids common to the .gamma.chain of sub-unit A of the cholera toxin and the .gamma.chain of the LT toxin of Escherichia coli. The peptide is preferably constituted by a pentadecapeptide which corresponds to the following formula (I): ##STR1## The process of synthesis is by the step by step construction of the peptide chain starting form the C terminal end of said chain, by the successive fixing of the amino acids which constitute the peptide. A novel medicament for the treatment of cholera and infectious gastro-enterites is also disclosed which comprises said synthetic peptide as an active constituent. A diagnosis agent for cholera and/or infectious gastroenterites comprises a sequence of at least the 5 amino acids of the synthetic peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.