Patent · US Expired

Method and composition for regulating serum calcium levels of mammals

US4692433A · kind A · utility

90Cited by

4References

22Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Karl Y. Hostetler · Del Mar, US
Leonard J. Deftos · Del Mar, US

Key dates

Filing date	Aug 1, 1985
Grant date	Sep 8, 1987
Priority date	—
Expiry date	Aug 1, 2005

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/29
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Method for regulating serum calcium levels in mammals by orally administering a composition which includes a polypeptide hormone such as parathyroid hormone (PTH) or calcitonin. The polypeptide hormone is protected from destruction in the digestive tract by encapsulation in liposomes. The liposome preferably includes a cationic amphiphilic agent so that the surface of the liposome has a net positive charge. Agents for enhancing the action of the liposome encapsulated hormones are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.