Soluble interleukin-2 receptor as a disease indicator and a method of assaying the same

US4707443A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• David R. Nelson · Lompoc, US
• William Biddison · Bethesda, US
• Laurence Rubin · Bethesda, US
• Warner C. Greene · Chapel Hill, US
• Warren J. Leonard · Bethesda, US
• Robert Yarchoan · Bethesda, US

Key dates

• Filing date: Apr 19, 1985
• Grant date: Nov 17, 1987
• Expiry date: Apr 19, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/868
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention discloses a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample. The method comprises determining reactivity of said sample with a plurality of ligands, each said ligand having binding affinity for a specific site on the receptor, said site being different for each said ligand and distinct from interleukin-2 binding site on the receptor. The invention also discloses a method of detecting such disturbed or abnormal conditions in humans which release soluble IL-2R in the body fluid.