Chemotactic assay for immunogenicity
US4714674A · kind A · utility
14Cited by
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25Claims
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Assignee
Inventor
Key dates
| Filing date | Feb 28, 1985 |
| Grant date | Dec 22, 1987 |
| Priority date | — |
| Expiry date | Feb 28, 2005 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5008
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The in vitro chemotactic activity of recombinant protein compositions is a predictive test for in vivo immunogenicity. Recombinant synthesis methods and subsequent purification or processing techniques are modified in the light of the chemotactic assay results in order to reduce or enhance the in vivo immunogenicity of the compositions. The invention ameliorates a major cost and source of uncertainty in the development of recombinant protein compositions. Immunogenicity of substances in vivo is modulated by binding chemotactic polypeptides thereto.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.