Hybrid particle immunogens
US4722840A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 19, 1985 |
| Grant date | Feb 2, 1988 |
| Priority date | — |
| Expiry date | Sep 19, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel immunogenic compositions are provided involving viral particles composed at least in part of hybrid proteins of at least a portion of a particle forming protein and one or more polypeptides having at least one epitope of interest. Nucleic acid sequences are employed coding for the hybrid protein which are introduced into a host cell for expression, either by themselves or in combination with other DNA sequences coding for particle forming proteins. Expression of the DNA sequences results in formation of particles which may be isolated and used as immunogens for production of antibodies for diagnostics purposes, passive immunization, vaccination, or other uses. Saccharomyces carlsbergensis, 2150-2-3 (pDC103), was deposited on Sept. 7, 1984, at the ATCC and given ATCC Accession No. 20726. Also, Saccharomyces cerevisiae PO17 (pC1/1-MCS29) was deposited at the ATCC on Sept. 5, 1985, and given ATCC Accession No. 20770.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.