Pharmaceutical preparations containing cyclodextrin derivatives
US4727064A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 29, 1985 |
| Grant date | Feb 23, 1988 |
| Priority date | — |
| Expiry date | May 29, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0012
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention comprises pharmaceutical preparations consisting generally of a drug with a substantially low water solubility and an amorphous, water-soluble cyclodextrin-based mixtures. In these preparations a stable amorphous state can be achieved. This improves the dissolution properties of the drug and hence its absorption by the body. The required cyclodextrin-based mixtures were prepared from .alpha.-, .beta.-, or .gamma.-cyclodextrin which were rendered amorphous through non-selective alkylation. The alkylation agents suitable for that purposes are exemplified by propylene oxide, glycidol, iodoacetamide, chloroacetate, or 2-diethylaminoethylchloride; their reactions with cyclodextrins were performed in a manner to yield mixtures containing many components, a circumstance which effectively prevents crystallization processes within the above pharmaceutical preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.