D-mannite derivatives as starting products for the synthesis of phospholipids

US4734225A · kind A · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventor

• Hansjorg Eibl · Bovenden, DE

Key dates

• Filing date: Mar 5, 1984
• Grant date: Mar 29, 1988
• Expiry date: Mar 5, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/2458
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The mannite derivatives have the formula (1) wherein R' and R.sup.2, idenal or different, represent when they are identical a straight or branched alkyl, alkenyl or alkynyl group containing from 5 to 24 atoms of carbon which may be substituted by a cycloalkyl residue having from 3 to 6 atoms of carbon, an aryl, benzyloxy, allyloxy, mesyloxy residue and/or halogen atoms and when R' and R.sup.2 are different, they represent a straight or branched alkyl group with 1 to 24 atoms or carbon, which may be substituted by a cycloalkyl residue having from 3 to 6 atoms of carbon, an aryl, benzyloxy, allyloxy, mesyloxy residue and/or halogen atoms, with the possibility for R' of being also a trityl group. From said mannite derivatives, it is possible to obtain in a simple way and with good yields the phospholipids in the form of their optical stereo isomers. ##STR1##