Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US4757141A · kind A · utility
281Cited by
6References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 26, 1985 |
| Grant date | Jul 12, 1988 |
| Priority date | — |
| Expiry date | Aug 26, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0039
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The compounds of the invention include novel linking agents comprising 2-substituted-3-protected-1,3,2-oxazaphosphacycloalkanes and their phosphoramidite precursors. The compounds of the invention further include conjugates of the above linking agents with oligonucleotides and polymer supports. The compounds of the present invention are useful for linking organic moieties, such as fluorescent or chromogenic dyes, to polymer supports and oligonucleotides, particularly single- and double-stranded DNA and RNA fragments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.