Metaphit and related compounds as acylating agents for the (3H)phencyclidine receptors

US4762846A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Kenner C. Rice · Bethesda, US
• Michael Francis Rafferty · Wheeling, US
• Arthur E. Jacobson · Rockville, US
• Patricia C. Contreras · West Chester, US
• Thomas L. O'Donohue · Chesterfield, US
• Ralph A. Lessor · New Providence, US
• Mariena V. Mattson · Rockville, US

Key dates

• Filing date: Jan 31, 1986
• Grant date: Aug 9, 1988
• Expiry date: Jan 31, 2006

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/9486
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A derivative of phencyclidine (1) bearing an isothiocyanate moiety on the meta position of the aromatic ring (3; Metaphit as methanesulfonate and HCl salt) has been synthesized and identified as a rapid and specific site-directed acylating agent of the [.sup.3 H]-phencyclidine binding site in rat brain homogenates. Additional related compounds to Metaphit are Thiophit (oxalate salt), Ethylphit (HCl salt), and Isopropylphit (HCl salt).