2,4-diamino-5[4-amino (or dimethylamino)-3,5-dimethoxybenzyl]pyrimidine and antibacterial composition thereof
US4792557A · kind A · utility
1Cited by
9References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1987 |
| Grant date | Dec 20, 1988 |
| Priority date | — |
| Expiry date | Jan 14, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/155
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.