Adeno-associated virus as eukaryotic expression vector

US4797368A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Barrie J. Carter · Kensington, US
• Jon Duri Tratschin · Bolligen, CH

Key dates

• Filing date: Mar 15, 1985
• Grant date: Jan 10, 1989
• Expiry date: Mar 15, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14143
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to a vector comprising part of AAV DNA contained in a plasmid and capable of being packaged into AAV particles and functioning as a vector for stable integration and expression of a gene in eukaryotic cells when under control of an AAV transcription promoter. A method of preparing such plasmids which are packagable and rescuable is also described.