Renin inhibitors and aminoacid and aminoaldehyde derivatives

US4818748A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Wolfgang Bender · Wuppertal, DE
• Rolf Henning · Wuppertal, DE
• Andreas Knorr · Erkrath, DE
• Johannes-Peter Stasch · Wuppertal, DE

Key dates

• Filing date: Mar 6, 1987
• Grant date: Apr 4, 1989
• Expiry date: Mar 6, 2007

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/86
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Anti-hypertensive compounds of the formula ##STR1## in which A represents hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.7 -C.sub.14 -aralkyl, phenylsulphonyl, tolylsulphonyl or C.sub.1 -C.sub.8 -alkylsulfphonyl, or represents an aminoprotective group, PA0 B represents a direct bond, or represents sarcosyl, or represents a group of the formula ##STR2## D represents a direct bond, or represents a group of the formula ##STR3## wherein X represents methylene, ethylene or sulphur, PA0 E, G, J, K, L and M independently have the same meanings as B, PA0 R.sup.1 is an optionally substituted phenyl radical, and PA0 Q is a hydroxy, alkoxy or amino group, or a physiologically acceptable salt thereof.